Discovering a new fashion of regulation in red blood cell production

A research team has discovered a mechanism in which blood stem cells respond to acute, severe anemia, through lipoprotein metabolism modification. It has been known how immediate erythroid precursors respond under acute anemic conditions, however, whether and how more immature stem cells react remained unknown. The outcome of this research is expected to contribute to the development of novel therapies for treating severe anemia patients who do not respond to existing treatments.